Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis

Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis

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Background: Many studies have assessed the potential link between interleukin-6 essie tea and crumpets polymorphisms and susceptibility to allergic diseases.However, the results are still conflicting.Therefore, a comprehensive meta-analysis can not only resolve differences but also provide clues for future projects.Methods: A systematic electronic search was conducted on the databases of Web of Science, PubMed, and Cochrane Library to retrieve all published studies.

Revman and Stata software were used for statistical analysis.Results: This meta-analysis included 11 studies.The results revealed that there was a statistically significant association between IL-6 rs1800795 polymorphism and the risk of asthma and allergic rhinitis in the general population.Subgroup analyses demonstrated that rs1800795 affected allergic diseases risk in different storm pourers populations.

Conclusion: Our findings suggested that IL-6 rs1800795 was associated with allergic diseases susceptibility among Asians and Caucasians in opposite trends, and it might influence the risk of asthma and allergic rhinitis.None of the IL-6 polymorphisms were shared risk variants of allergic diseases.